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+1/p-1/b10-9+
orally bioavailable (transient receptor potential melastatin member 8) TRPM8 agonist
Exposure of cells to Genz-123346 and to other GCS inhibitors at non-toxic concentrations can enhance the killing of tumor cells by cytotoxic anti-cancer agents
InChiKey: MAHASPGBAIQZLY-RTQZJKMDSA-N
UBP-282 inhibits the fast component of the dorsal root-evoked ventral root potential (fDR-VRP) with an IC50 value of 10
α-Guanidinoglutaric Acid rulline +1/p-1/b10-9+Guanidinoglutaric Acid is a novel nitric oxide synthase inhibitor with Ki value of 2. 69 M . In the brain, nitric oxide (NO), which is synthesized from L arginine (Arg) by NO synthase (NOS), acts as both an intra and an intercellular second messenger, and it may suppress convulsions . Guanidinoglutaric Acid (GGA) is a novel nitric oxide synthase inhibitor. GGA was increased in the cobalt induced epileptic focus tissue in the cerebral cortex of cats .